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HongKong Curegene Innovation Co Limitedce86017d-f953-f111-bec6-7ced8de51a47_CompanyLogo_12082026

HongKong Curegene Innovation Co., Limited

Company

Established in 2018 in Zhangjiang Hi-Tech Park, Shanghai, CureGene Pharmaceutical is a global-oriented innovative biotech firm concentrating on two core therapeutic areas: cardio-cerebrovascular diseases and antiviral infectious diseases.
We have built two world-leading self-owned technology platforms: A-proX™ AI Prodrug Platform and CureGene-X1 mRNA Therapeutic Platform, supporting the full-cycle discovery, preclinical and clinical development of differentiated First-in-Class/Best-in-Class drug candidates with global independent intellectual property rights.
Our core pipeline includes Evategrel (CG-0255, novel dual-form P2Y12 antiplatelet agent), liver-targeted THR-β agonist CG-0416 for metabolic disorders, and therapeutic HBV vaccine CG-1999 for functional cure of hepatitis B. Multiple assets have entered global multi-center clinical trials in the US, Australia and China.
Led by Dr. Gongxin He, former senior R&D leader at Gilead Sciences, our core team consists of veteran scientists and executives from top multinational pharma, with profound expertise covering drug design, clinical operation and global commercialization. In Q1 2026, we completed nearly USD 47 million Series C financing to accelerate worldwide clinical advancement of all pipeline programs.
Adhering to our mission Bring Benefit to Patient, Create Value for the Society, CureGene leverages HKSTP’s international ecosystem to expand cross-border BD, investor communication and global clinical resource cooperation, delivering breakthrough therapies addressing unmet clinical demands for patients worldwide.

Description

Founded in Zhangjiang Shanghai in 2018, CureGene is a clinical-stage biotech focusing on cardio-cerebrovascular and antiviral innovative drugs, empowered by proprietary A-proX™ prodrug and CureGene-X1 mRNA platforms.

Our Beliefs

Bring Benefit to Patient
Create Value for the Society

Product

Evategrel (CG-0255) is a dual-form (intravenous + oral) novel P2Y12 antiplatelet prodrug developed based on the A-proX™ AI prodrug platform. It balances rapid onset, stable platelet inhibition and excellent bleeding safety profile, indicated for acute coronary syndrome and ischemic stroke. Multiple clinical trials are underway in China and the United States.

Technology

Two Proprietary Core Technology Platforms
A-proX™ AI Prodrug Platform: AI-assisted chemical modification to design tissue-targeted prodrugs, improving drug efficacy, safety and pharmacokinetic profiles, forming solid patent barriers for CG-0255, CG-0416 and other pipeline assets.
CureGene-X1 mRNA Therapeutic Platform: Modular integrated mRNA R&D system for therapeutic vaccines against infectious diseases such as HBV, supporting CG-1999 development.
Self-developed Global Clinical Pipeline
Cardio-cerebrovascular: Evategrel (CG-0255, IV & oral P2Y12 inhibitor) for stroke, ACS;
Metabolic Disorder: CG-0416 liver-target THR-β agonist for obesity & MASH;
Antiviral: CG-1999 therapeutic mRNA vaccine for HBV functional cure.