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Pamplona Therapeutics HK Limited2cd97acd-e827-f111-88b3-7ced8de5112c_CompanyLogo_23042026

潘普洛納生物科技(香港)有限公司

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公司

Pamplona Therapeutics is an early-stage drug discovery company developing targeted protein degradation (TPD) therapy to address unmet needs in autoimmune and oncology diseases. The company has built a cutting-edge, AI-driven TPD drug discovery platform (ASTRIDE®) that integrates target structure prediction, high-throughput virtual screening, molecular docking, molecule generation, and ubiquitination assessment modules. Harnessing this AI-driven platform, Pamplona advanced its first autoimmune-focused preclinical candidate within 18 months of its inception, and its first IND was cleared by the FDA at the end of 2025. With this proven and highly scalable AI-based platform, we aim to tackle additional undruggable targets and address a broad range of global disease challenges.

简介

AI Meets Protein Degradation: Redefining Medicine

团队的信念

Transform healthcare through groundbreaking innovation

产品

Our lead program is a clinical-stage drug candidate targeting autoimmune diseases, built on a novel, differentiated mechanism of action. It has successfully secured IND clearances in both China and the U.S., validating our robust translational expertise and global regulatory readiness, while addressing substantial unmet medical needs for patients worldwide.
Complementing our pipeline, we have established a proprietary ASTRIDE platform that integrates rational degrader design with a rigorous ubiquitination assessment system. Highly scalable and versatile, this platform enables rapid expansion across a wide range of targets, fueling the advancement of a diversified pipeline spanning first-in-class and best-in-class therapeutic modalities.
Collectively, our clinical assets and foundational platform constitute a distinctive, scalable innovation engine. This integrated strategy drives continuous pipeline generation and progression, positioning us to deliver transformative therapies and achieve sustainable, long-term growth in the global biotech landscape.

技术

Target Protein Degradation Drug, AI-driven Structure-based TPD Rational Design Platform.